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Home - Products - Chromatin/Epigenetic - HMTase - Furamidine dihydrochloride

Furamidine dihydrochloride

CAS No. 55368-40-6

Furamidine dihydrochloride ( NSC 305831 dihydrochloride;WR 199385 )

Catalog No. M15013 CAS No. 55368-40-6

Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1).

Purity : >98% (HPLC)

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Biological Information

  • Product Name
    Furamidine dihydrochloride
  • Note
    Research use only, not for human use.
  • Brief Description
    Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1).
  • Description
    Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM; exhibits selectivity over PRMT5, PRMT6 and CARM1 (>15-fold); binds duplex DNA in the DNA minor groove selectively at AT rich sites [(A/T)4], Furamidine can also intercalate between GC base pairs of duplex DNA, bind CTG-CAG repeat DNA with nanomolar affinity; synergistically suppresses murine lupus nephritis in vivo combined with Irinotecan; effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions.
  • Synonyms
    NSC 305831 dihydrochloride;WR 199385
  • Pathway
    Chromatin/Epigenetic
  • Target
    HMTase
  • Recptor
    HMTase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    55368-40-6
  • Formula Weight
    377.27
  • Molecular Formula
    C18H18Cl2N4O
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    C1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N
  • Chemical Name
    Benzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-, dihydrochloride (9CI)

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Antony S, et al. Nucleic Acids Res. 2007;35(13):4474-84.
2. Jenquin JR, et al. ACS Chem Biol. 2018 Aug 27. doi: 10.1021/acschembio.8b00646.
3. Keil A, et al. Arthritis Rheumatol. 2015 Jul;67(7):1858-67.
4. Yan L, et al. J Med Chem. 2014 Mar 27;57(6):2611-22.
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