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Furamidine dihydrochloride
CAS No. 55368-40-6
Furamidine dihydrochloride ( NSC 305831 dihydrochloride;WR 199385 )
Catalog No. M15013 CAS No. 55368-40-6
Furamidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1).
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
| Size | Price / USD | Stock | Quantity |
| 5MG | 194 | Get Quote |
|
| 50MG | 737 | Get Quote |
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| 100MG | 1107 | Get Quote |
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| 200MG | Get Quote | Get Quote |
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| 500MG | Get Quote | Get Quote |
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| 1G | Get Quote | Get Quote |
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Biological Information
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Product NameFuramidine dihydrochloride
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NoteResearch use only, not for human use.
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Brief DescriptionFuramidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1).
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DescriptionFuramidine dihydrochloride (NSC 305831, WR 199385) is an inhibitor of tyrosyl-DNA phosphodiesterase (Tdp1), also is a selective protein arginine methyltransferase 1 (PRMT1) inhibitor with IC50 of 9.4 uM; exhibits selectivity over PRMT5, PRMT6 and CARM1 (>15-fold); binds duplex DNA in the DNA minor groove selectively at AT rich sites [(A/T)4], Furamidine can also intercalate between GC base pairs of duplex DNA, bind CTG-CAG repeat DNA with nanomolar affinity; synergistically suppresses murine lupus nephritis in vivo combined with Irinotecan; effectively inhibits intracellular PRMT1 activity and blocks cell proliferation in leukemia cell lines with different genetic lesions.
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SynonymsNSC 305831 dihydrochloride;WR 199385
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PathwayChromatin/Epigenetic
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TargetHMTase
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RecptorHMTase
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Research Area——
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Indication——
Chemical Information
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CAS Number55368-40-6
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Formula Weight377.27
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Molecular FormulaC18H18Cl2N4O
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Purity>98% (HPLC)
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Solubility——
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SMILESC1=CC(=CC=C1C2=CC=C(O2)C3=CC=C(C=C3)C(=N)N)C(=N)N
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Chemical NameBenzenecarboximidamide, 4,4'-(2,5-furandiyl)bis-, dihydrochloride (9CI)
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Antony S, et al. Nucleic Acids Res. 2007;35(13):4474-84.
2. Jenquin JR, et al. ACS Chem Biol. 2018 Aug 27. doi: 10.1021/acschembio.8b00646.
3. Keil A, et al. Arthritis Rheumatol. 2015 Jul;67(7):1858-67.
4. Yan L, et al. J Med Chem. 2014 Mar 27;57(6):2611-22.
2. Jenquin JR, et al. ACS Chem Biol. 2018 Aug 27. doi: 10.1021/acschembio.8b00646.
3. Keil A, et al. Arthritis Rheumatol. 2015 Jul;67(7):1858-67.
4. Yan L, et al. J Med Chem. 2014 Mar 27;57(6):2611-22.
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